Responsibility：
? Develop establish preclinical in vivo models fAlzheimer’s disease (AD),
Parkinson’s disease (PD), stroke, pain-related CNS disorders to evaluate novel
therapeutics.
? Work closely with Medicinal Chemistry, Biologics Discovery, in vitro Pharmacology,
DMPK, Toxicology teams to design execute in vivo pharmacology studies,
supporting target validation, pharmacokinetics (PK), pharmacodynamics (PD).
? Design conduct behavioral, biochemical, molecular assays in rodent
models to assess drug efficacy, mechanism of action (MoA), biomarker
responses.
? Collaborate with cross-functional teams to develop in vivo proof-of-concept (PoC)
studies, ensuring alignment with program milestones.
? Serve as a subject matter expert in CNS disease model development, providing
insights on experimental design, troubleshooting, data interpretation.
? Perform tissue collection biomarker assessments using molecular, histological,
biochemical techniques (IHC, IF, qPCR, ELISA, MSD, Luminex, Western blot).
? Mentmanage juniscientists research associates, providing
scientific/technical guidance, performance feedback, professional development.
? Contribute to the evaluation of new drug targets, MoA studies, proposal第 2 頁 共 4 頁
preparation fCNS drug discovery programs.
? Support IND-enabling studies participate in regulatory document preparation
fclinical submission.
Qualifications：
? PhD (with at least 3 years of industry experience) in neuroscience,
neuropharmacology, behavioral neuroscience, related fields.
? Hands-on experience in CNS in vivo pharmacology, with proven expertise in AD,
PD, stroke, pain models.
? Proficiency in rodent handling, stereotaxic surgeries, behavioral assays, drug
administration (IV, IP, SC, ICV, IT, PO, etc.).
? Extensive experience in ex vivo neuropharmacology techniques, including flow
cytometry, ELISA, multiplex cytokine analysis, Western blot, transcriptomics
(RNA-seq, proteomics).
? Proven track-record of supporting CNS projects IND submission familiar with
China NMPA/the US FDA IND submission requirements fCNS in vivo
pharmacology.
? Strong ability in literature patent research, analytical thinking, problemsolving.
? Excellent verbal written communication skills in English (CET6/IELTS/TOEFL/GRE
scores preferred).
? Highly collaborative team player with strong interdisciplinary communication
skills.
Key Expertise in Model Establishment Experimental Techniques：第 3 頁 共 4 頁
Alzheimer’ s Disease (AD) Models
? Transgenic models (e.g., APP/PS1, 5xFAD, Tauopathy models)
? Aβ tau injection models (ICV stereotaxic injection)
? Cognitive behavioral assays (e.g., Morris water maze, novel object recognition, Y-maze,
fear conditioning, radial arm maze)
? Neuroinflammation glial activation assessment
Parkinson’s Disease (PD) Models
? Neurotoxin-based models (e.g., MPTP, 6-OHDA lesion models)
? α-synuclein preformed fibril (PFF) injection models
? Behavioral tests fmotfunction (e.g., rotarod, pole test, open field, gait analysis)
? Dopaminergic neuron degeneration analysis (e.g., TH staining, dopamine
quantification)
Stroke Models
? Middle Cerebral Artery Occlusion (MCAO) model including pMCAO, tMCAO and
eMCAO models
? Photothrombotic ischemia model
? Neurological motfunction assessments (e.g., neurological deficit score, cylinder
test, adhesive removal test)
? Histological molecular assessment of infarct size neuroprotection
Pain-related CNS Disease Models
? Neuropathic pain models (e.g., spinal nerve ligation (SNL), chronic constriction injury
(CCI), chemotherapy-induced neuropathy)
? Inflammatory pain models (e.g., CFA-induced paw inflammation, formalin test)第 4 頁 共 4 頁
? Pain sensitivity assessments (e.g., von Frey test, hot plate, Hargreaves test, mechanical
allodynia)